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CYP2D6 genotyping of breast cancer patients under treatment with tamoxifen in Gaza Strip

Ayesh, Adham A (الجامعة الإسلامية - غزة, 2016)

Introduction: Tamoxifen is the standard antihormonal therapy for breast cancer. It undergoes chemical digestion to more active compounds inside the liver microsome through the cytochrome P450 isoform CYP2D6, an enzyme ...

Follicle-Stimulating Hormone Receptor Polymorphism in Infertile Palestinian Men

Nahal, Nader (الجامعة الإسلامية - غزة, 2016)

Background: Follicle stimulating hormone (FSH) is a pituitary glycoprotein, which is necessary for normal reproduction in both male and female mammals. Follicle stimulating hormone receptor (FSHR) signaling stimulates ...

Genetic Polymorphisms in Lung Cancer Susceptibility between Palestinian Population (Gaza Strip)

Al Masri, Rami (الجامعة الإسلامية - غزة, 2015)

Lung cancer is a leading cause of cancer-related deaths throughout the world. Recent GWAS and consecutive validation supported that SNPs in the 15q25, 5p15.33 and 6p22 regions showed significant association with lung cancer ...

Investigating the Association between Polymorphism of Follicle Stimulating Hormone Receptor Gene at Codon 680 with Ovarian Stimulation in Palestinian Women Undergoing IVF

Deibes, Mahmoud Dawoud (الجامعة الإسلامية - غزة, 2015)

Background: Follicular Stimulation Hormone (FSH) is essential for normal gonadal function and it is action is mediated by FSH receptor (FSHR). Single nucleotide polymorphisms (SNPs) of FSHR determine the ovarian response. ...

SLCO1B1 (c.521t<c) and CYP3A4(c.522-191c<t) GENES POYMORPHISM AND STATIN - INDUCED MUSCLE PAIN IN CORONARY HEART DISEASE PATIENTS IN GAZA STRIP

ALRANTISI, YOUSEF JAMAL (الجامعة الإسلامية - غزة, 2014)

Evaluating the Role of Diet ,Life Style , and Leptin Receptor (LEPR) Gln223Arg Gene Polymorphism as Risk Factors for Obesity among Secondary School Girls in Gaza Strip

Farboua, Dalin H (الجامعة الإسلامية - غزة, 2013)

Introduction: Obesity is one of the most prevalent diseases worldwide today. It results from a combined effects of, environmental, lifestyle, and genetic factors. The leptin receptor gene plays a critical role in the ...

Effect of Origanum syriacum, Hibiscus sabdariffa, Thymus vulgaris and Pelargonium graveolens Extracts on Human Leukemia THP-1 Cells in Vitro

Faris, Doa''a (الجامعة الإسلامية - غزة, 2013)

Introduction: Leukemia is an aggressive disease that if untreated it leads to death. Because the conventional leukemia treatment protocols are not effective in all cases and result in serious side effects, discovering new ...

Allelic Variants of CYP2C9 and VKORC1 Genes and their Relation to Warfarin Metabolism in Patients Under Warfarin Therapy in Gaza Strip

Shaaban, Ahmed Shaker Abu (الجامعة الإسلامية - غزة, 2013)

Background: Warfarin is the most widely prescribed oral anticoagulant for thromboembolic therapy, patient management is difficult because of significant differences in metabolic rates as a result of allelic variation in ...

Reproductive Factors and Common Genetic Mutations Associated with Breast Cancer Risk in Gaza Strip

Saleh, Mysserah Salim Abdel Hameed (the islamic university, 2011)

Context and objective: BRCA1 and BRCA2 are the two principal hereditary breast cancer susceptibility genes, and the incidence of their mutations among breast cancer patients in Gaza Strip is unknown. The objective was to ...

Thiopurine Methyltransferase Genotyping in Childhood Acute Lymphoblastic Leukemia Patients in Gaza Strip

Harb, Wael Mohammed Mahmoud (the islamic university, 2010)

Background: The genetic polymorphism of thiopurine methyltransferase (TPMT) is well characterized in most populations. Three common polymorphic alleles are associated with impaired activity of the enzyme. These are TPMT*2 ...