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Investigating aneuploidy-inducing effect of Nemacur, Rogor, and Dursban in human peripheral blood lymphocyte cultures

Abuwarda, Hadeer; Ashi, Shadi; Sharif, Fadel (2021-06)

For many years, organophosphate (OP) pesticides have been considered an attractive choice for pest control around the world. Excessive use of OPs is a concerning issue for human health. Although the genotoxic effect of ...

Anticancer activity of Rosemary (Rosmarinus officinalis L.) and Oats (Avena sativa L.) Extracts, and their antitumor enhancement of 5-Fluorouracil on Colon Cancer Caco-2 Cell Line

El-burai, Hadil; Alzaharna, Mazen; Isleem, Rajy; El-Hindi, Mahmoud; Sharif, Fadel (AKINI PUBLISHERS, 2020-04)

Colorectal cancer is one of the commonest tumors worldwide, and the third cause of death among all cancers. Over the years, several herbal plants have proved efficacy in modulating this disease. In this study, plant parts ...

Synergistic anticancer effect of combining metformin with olive (Olea europaea L.) leaf crude extract on the human breast cancer cell line MCF-7

Isleem, Rajy; Alzaharna, Mazen; Sharif, Fadel (AKINI PUBLISHERS, 2020-02)

Breast cancer is one of the most prevalent cancers among women globally. Several in vitro studies have shown that Metformin and Olive (Olea europaea L.) Leaf extract have anticancer activity when applied separately. This ...

Partial Trisomy of Chromosome 13 with a Novel Translocation (8 ; 13) and Unique Clinical Presentation in a Palestinian Infant

Abuhamda, Allam; Elsous, Aymen; Sharif, Fadel (Hindawi Limited, 2019-02-26)

Partial trisomy 13 is a rare syndrome that usually culminates in death within the first six months of the infant's life. We present a rare case of partial trisomy 13q with exclusive clinical manifestations. The full-term ...

Frequency of balanced reciprocal translocations from couples with recurrent miscarriages correlates with the density of Alu and L1 repeat elements: literature finding‑based study

Sharif, Fadel (Wolters Kluwer - Medknow, 2019)

Balanced reciprocal translocations constitute the most frequently encountered structural chromosome abnormality in couples experiencing recurrent miscarriages. The present work was undertaken to assess the relation between ...

Genetic polymorphism and risk of having type 2 diabetes in a Palestinian population: a study of 16 gene polymorphism

Sharif, Fadel; Shubair, Mohammad; AL Zaharna, Mazen; Ashour, Mohammed (Avens Publishing Group, 2018)

Background: Type 2 Diabetes (T2D) is a multifactorial disease that encompasses environmental risk factors and the contribution of multiple genomic variants. Studies on the genetic components of T2D revealed many T2D-associated ...

Langerhans Cell Histiocytosis: The First reported case from Palestine

Sharif, Fadel; Salibi, Thiab; Ashour, Mohammed (2018)

Langerhans cell histiocytosis (LCH) is a rare clonal neoplasm of the antigen presenting Langerhans cells. This case report presents a 29-years old Palestinian white male who visited the university clinic dentist with ...

Endothelial nitric oxide synthase (eNOS) gene polymorphism, nitric oxide and progesterone levels in unexplained recurrent pregnancy loss

El-Gharably, Emad M; Sharif, Fadel A. (2017)

This study was conducted in order to determine the relationships between promoter-786 T> C, exon 7 Glu298Asp (894 G> T) and intron 4 (4a4b) VNTR polymorphisms of eNOS gene, serum nitric oxide (NO) and progesterone (P4) ...

Nphs2 Mutations in Familial Steroid Resistant Nephrotic Syndrome in Gaza

Sharif, Fadel A. (2017)

Background: Nephrotic syndrome (NS) is characterized by edema, massive proteinuria, hypoalbuminemia, hyperlipidemia, and may progress to end stage renal disease. Based on the response to steroid therapy, NS is categorized ...

The single nucleotide polymorphism rs2305957 G/A is not associated with recurrent pregnancy loss

Sharif, Fadel A.; Ashour, Mohammed J. (2017)

Background: This study was conducted in order to investigate the association between the single nucleotide polymorphism (SNP) rs2305957 G/A and recurrent pregnancy loss (RPL) in a group of Palestinian women residing in ...

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