Numerical Investigation of Localized Surface Plasmon Resonance (LSPR) based Sensor for Glucose Level Monitoring

Abstract

This study aims to apply Localized Surface Plasmon Resonance (LSPR), Maxwell Garnett’s formula, and Fabry-Perot theory together to design and develop a LSPR enhanced gold colloidal nanoparticles (AuNPs) sensor to be used in biomedical applications such as detection of glucose level in urine for early stage screening of diabetic patients. In this work, the LSPR based sensor has been designed and studied numerically to detect the glucose level from the change in the effective index resulting in a red shift of the absorption peak. The sensors were designed to have various sizes of the gold nanoparticles in a range between 20 nm and 100 nm by having different molar ratio with Trisodium Citrate (TSC) which acts as stabilizer in the synthesis. The maximum possible sensitivity of the sensor can be achieved with 70 nm diameter of gold nanoparticles at 0.2 volume fraction of AuNP to glucose solution