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Please use this identifier to cite or link to this item:

http://hdl.handle.net/20.500.12358/27125
TitleThe palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells
Title in Arabicتأثير مركب بالاديوم AJ-5 على خلايا سرطان الثدي و الخلايا الجذعية السرطانية
Abstract

Breast cancer is the most common malignancy amongst women worldwide but despite enormous efforts to address this problem, there is still limited success with most of the current therapeutic strategies. The current study describes the anti-cancer activity of a binuclear palladacycle complex (AJ-5) in oestrogen receptor positive (MCF7) and oestrogen receptor negative (MDA-MB-231) breast cancer cells as well as human breast cancer stem cells. AJ-5 is shown to induce DNA double strand breaks leading to intrinsic and extrinsic apoptosis and autophagy cell death pathways which are mediated by the p38 MAP kinase. This study provides evidence that AJ-5 is potentially an effective compound in the treatment of breast cancer.

Authors
Aliwaini, Saeb H.
Peres, Jade
Kröger, Wendy L.
Blanckenberg, Angelique
de la Mare, Jo
Edkins, Adrienne L.
Mapolie, Selwyn
Prince, Sharon
TypeJournal Article
Date2015-02
LanguageEnglish
Subjects
Apoptosis
Autophagy
Breast cancer
Cancer stem cells
P38 MAPK
Palladacycles
Published inCancer Letters
SeriesVol. 357, No. 1
PublisherElsevier BV
Citation
Item linkItem Link
DOI10.1016/j.canlet.2014.11.027
ISSN03043835
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  • Staff Publications- Faculty of Science [1030]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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