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http://hdl.handle.net/20.500.12358/26751
TitleSynthesis and antibacterial activity of crossed aldol products
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Abstract

Abstract A number of [alpha],[beta]-unsaturated carbonyl compounds were prepared by condensing of 2-formylfuran, 2-formylpyridine and 2-formylthiophene with acetone, acetophenone, 3-methyl-acetophenone,[alpha]-chloroacetophenone and ethyl methyl ketone in ethanolic NaOH solutions. These compounds were tested for antibacterial activity against Escherichia coli.(E. coli). It was found that the mesomeric and the hyperconjugation effects have a strong influence on the antibacterial activity. Introduction Crossed aldol (Claisen-Schmidt) type reaction of 2-formylpyrrole, 2-formylfuran or 2-formyl thiophene with active methylene compounds gave [alpha],[beta]-unsaturated carbonyl compounds in high yields [1].[alpha],[beta]-Unsaturated carbonyl compound derivatives were reported to be active as antibacterial, antifungal, antimutagenic, anticancer, antioxidant, anticoagulant, antiangiogenesis, antitumor and …

Authors
Hania, Majed
Abo-Sharkia, Tarik
TypeJournal Article
Date2007
Published inInternational Journal of Applied Chemistry
SeriesVolume: 3, Number: 1
PublisherResearch India Publications
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  • Staff Publications- Faculty of Science [1030]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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