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|Title||Evaluation of routes to chiral core dendrimers|
Dendrimers are macromolecules with a highly branched three-dimensional shape, produced in an iterative sequence of reaction steps, in which each reaction results in a new generation. Dendrimers have stimulated wide interest in the field of chemistry and biology, particularly with respect to applications to drug delivery and more recently imaging. They have also been of growing interest as macromolecular hosts, potential catalysts and have been attached to surfaces and polymeric materials, and have significant potential in new materials development. Dendrimers can have comparable molecular dimensions to some proteins and could potentially have internal microenvironments akin to the active site of an enzyme. Encapsulation within dendrimers has significant potential biomedical applications, whilst dendrimer surface behavior is of interest to evaluate interactions of dendrimer surface functionality (its most accessible region) with biological molecules. Exploiting many of these areas are dependent on generating chirality in dendrimers.
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|Morjan, Rami Y._13.pdf||1.549Mb|