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|Title||Substituted 1, 2-thiazetidine 1, 1-dioxides. Synthesis and properties of N-alkylated and N-acylated derivatives of 1, 2-thiazetidine-3-acetic acid 1, 1-dioxide|
1,2-Thiazetidine-3-acetic acid 1,1-dioxide was N-alkylated using bromoacetates, and N-acylated using either acyl chlorides, protected amino acid fluorides, or N-protected amino acid NCA, which seemed to be the most universal method. Most of the obtained “β-sultam peptides” were sensitive against humidity, they hydrolyzed forming sulfonic acids, and reactions with amines resulted in sulfonamides. Reactions of N-acylated products showed that the sulfonyl group was faster attacked than the imide structure.
|Published in||Monatshefte für Chemie/Chemical Monthly|
|Series||Volume: 135, Number: 1|
|Item link||Item Link|
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