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|Title||Synthesis and structure of 2-aryl-5, 5-disubstituted-1, 3-dioxanes and conversion into chiral (1, 1, 1-trishydroxymethyl) methane derivatives|
Pentaerythritol, (1,1,1-trishydroxymethyl)methyl methane and (1,1,1-trishydroxymethyl)nitromethane are converted into 2-aryl-5,5-bis(hydroxymethyl), 2-aryl-5-hydroxymethyl-5-methyl- or 2-aryl-5-hydroxymethyl-5-nitro-1,3-dioxanes and a range of derivatives. X-Ray and NMR analysis establishes that the latter is obtained as a single diastereomer whose structure is unambiguously determined. These materials can be elaborated to chiral derivatives of the starting (1,1,1-trishydroxymethyl) methanes.
|Published in||Tetrahedron letters|
|Series||Volume: 43, Number: 11|
|Item link||Item Link|
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|Morjan, Rami Y._2.pdf||173.6Kb|