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http://hdl.handle.net/20.500.12358/26138
Title | Ring Transformation of Heterocycles Transformation of 4, 5-Dihydro-5, 5-Dimethyl-H-1, 2, 4-Triazoles Into 5-Methyl-H-1, 2, 4-Triazoles |
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Untitled | |
Abstract |
Reaction of 1-aryl-3-acetyl-4, 5-dihydro-5, 5-dimethyl-1H-1, 2, 4-triazoles (3) with acetyl chloride or acetic anhydride is found to give the ring transformation product 1-aryl-3-acetyl-5-methyl-1H-1, 2, 4-triazoles (4) instead of the expected N-acetyl derivative (5). This ring transformation is believed to start with N-acylation of the dihydrotriazole (3) to form the corresponding N-acetyl derivative (5), which extrudes the actone via a four-membered ring intermediate (6) and recyclizes to the aromatic triazole (4) suggesting the conversion sequence (3)→(5)→(6)→(4). It is Also found that. The triazoles 4 can be prepared directly via a one put reaction between nitrilimines and acetaldoximes.(Author) 8 refs., 4 Sches |
Authors | |
Type | Journal Article |
Date | 2001 |
Published in | Abhath Al-Yarmouk. Pure Science and Engineering Series |
Series | Volume: 10, Number: 2A |
Citation | |
Item link | Item Link |
License | ![]() |
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