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http://hdl.handle.net/20.500.12358/26008
Title | Evaluation of CYP2C9- and VKORC1-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine |
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Untitled | |
Abstract |
Aim: To evaluate applicability of CYP2C9* 2,* 3 and VKORC1–1639G> A based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients. Patients & methods: Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD. Results: Frequency of CYP2C9* 2,* 3 and VKORC1–1639G> A alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE= 8.9±1.4; R2= 0.350) than both the clinical algorithm (MAE= 10.4±1.4; R2= 0.128;) and the fixed-dose algorithm (MAE= 11.1±1.7). Conclusion: The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population. |
Type | Journal Article |
Date | 2018 |
Published in | Future science OA |
Series | Volume: 4, Number: 3 |
Publisher | Future Science Ltd |
Citation | |
Item link | Item Link |
License | ![]() |
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