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http://hdl.handle.net/20.500.12358/26008
TitleEvaluation of CYP2C9- and VKORC1-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine
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Abstract

Aim: To evaluate applicability of CYP2C9* 2,* 3 and VKORC1–1639G> A based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients. Patients & methods: Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD. Results: Frequency of CYP2C9* 2,* 3 and VKORC1–1639G> A alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE= 8.9±1.4; R2= 0.350) than both the clinical algorithm (MAE= 10.4±1.4; R2= 0.128;) and the fixed-dose algorithm (MAE= 11.1±1.7). Conclusion: The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population.

Authors
Ayesh, Basim M.
Abu Shaaban, Ahmed Shaker
Abed, Abdalla
TypeJournal Article
Date2018
Subjects
gaza strip
vitamin k antagonist
vkorc1
warfarin
allelic frequency
cyp2c9
iwpc algorithm
pharmacogenetics
Published inFuture science OA
SeriesVolume: 4, Number: 3
PublisherFuture Science Ltd
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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