Blood indices of sodium-benzoate-administrated albino rats: effect of olive oil and/or time-dependent recovery

Abstract

The study aims to determine hematological and biochemical blood indices of male albino rats administered sodium benzoate for different periods of time, and to investigate the effects of olive oil and/or recovery time on these blood parameters. There were seven groups of six rats: the control group had distilled water; of the remaining six groups, three had olive oil and three not; in each group of three, all were administered the same amount of sodium benzoate, one for 12 days, and the other two for 26 days, but one of these was left for four weeks before blood measurements were taken to study the possibility of time dependent recovery. At the end of the experiment, blood collection and examination were carried out. Sodium benzoate increased white blood cells and lymphocytes, and decreased hematocrit, hemoglobin, red blood cell counts and platelets. Olive oil and four weeks of recovery time reduced the effects of sodium benzoate. Similar effects were evident for glucose and urea, and levels of creatinine, urea, uric acid, total protein, albumin, globulin cholesterol, triglycerides, alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase. Olive oil had some significant effects on enzyme levels.