Clarithromycin Resistance of Helicobacter pylori Infections in Gaza Strip, Palestine: نوفلؤملا

Abstract

Helicobacter pylori is the most widely spread bacterium worldwide, infecting more than half of the world population. Clarithromycin is the key component of treatment and clarithromycin resistance results in treatment failure. Therefore, the aim of this study is to evaluate the extent of clarithromycin resistance in H. pylori infected patients in Gaza strip. Biopsies were collected from different sites of the antrum of 87 symptomatic patients. The biopsies were formalin-fixed and paraffinembedded and 4µm thick slides were used for fluorescent in situ hybridization detection of the 3 common mutations (2143A> G, 2144A> G and 2143A> C) in the 23S rRNA leading to clarithromycin resistance.