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http://hdl.handle.net/20.500.12358/25312
TitleGlycodelin (PAEP) gene promoter polymorphism rs760140467 C>T is associated with recurrent pregnancy loss
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Abstract

In the absence of confirmed causes for around 50% of recurrent pregnancy loss (RPL) cases this study was conducted in order to evaluate the relationship between PAEP gene single nucleotide polymorphism (SNP) rs760140467 C> T and recurrent pregnancy loss (RPL) in Palestinian women. A retrospective case-control study was carried out during the period (August 2015 to April 2016). A total of 200 females, 100 RPL patients and 100 control women without previous history of RPL were included in the study. PAEP (rs760140467 C> T) polymorphism was tested by PCR-RFLP. Statistically significant difference existed between RPL cases and controls in terms of the genotypic and allelic distribution of the tested polymorphism. PAEP" T/C" genotype and" T" allele were significantly higher in the RPL group. The study showed, for the first time, that the" C/T" genotype and the" T'allele of the tested polymorphism are strongly associated with RPL in the investigated population. This finding may lead to improved therapeutic approaches for those RPL cases.

Authors
Sharif, Fadel A.
TypeJournal Article
Date2016
Subjects
paep gene
rs760140467 c>t
recurrent pregnancy loss _____________________________________________________________________________________________
polymorphism
Published inInternational Journal of Medical Research & Health Sciences
SeriesVolume: 4, Number: -
Publisherwww.ijmrhs.com
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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