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http://hdl.handle.net/20.500.12358/25308
TitleBeta-fibrinogen (-455 G/A) and Integrin beta-3 (PLA1/A2) polymorphisms and recurrent pregnancy loss in Gaza strip-Palestine
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Abstract

Background: This study was conducted in order to determine the relationship between the common polymorphisms in β-fibrinogen-455 G/A (rs1800790) and Integrin beta-3 T196C (PLA1/A2, rs5918) and recurrent pregnancy loss (RPL) in a group of Palestinian women residing in Gaza strip. Methods: The study presented here is a retrospective association study with a case-control design. The study population consisted of 102 women who suffered from RPL and 97 healthy women matched for age and without a previous history of RPL. DNA extracted from blood samples of all subjects was investigated for the β-fibrinogen (-455 G> A) and Integrin beta-3 (PLA1/A2) polymorphisms using PCR-RFLP and PCR-SSP, respectively. Results: The study revealed that β–fibrinogen-455G/A minor allele frequency (allele A) and its homozygous genotype (AA) were not significantly different between the RPL and the control groups. Likewise, there was no significant difference in the distribution of the ITGB-3 variant allele (PLA2) or PLA2/A2 genotype between the two groups. β–fibrinogen AA genotype was evident in 3.9% of the patients and in 4.1% of the controls (P-value= 0.94). The frequency of PLA2/A2 was observed in 2.0% of the patients and in 2.1% of the controls (P-value= 0.96). Conclusion: Results of the present study indicate that there is no significant association between the β–fibrinogen

Authors
Al-Astal, Manal G
Sharif, Fadel A.
TypeJournal Article
Date2016
Published inInternational Journal of Reproduction, Contraception, Obstetrics and Gynecology
SeriesVolume: 3, Number: 1
PublisherMedip Academy
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  • Staff Publications- Faculty of Health Sciences [192]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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