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|Title||HLA-G and HLA-E Gene polymorphisms in idiopathic recurrent spontaneous abortion women in Gaza strip-Palestine|
Human leukocyte antigens (HLA)-G and HLA-E are non-classical HLA class I antigens expressed on extravillous cytotrophoblast that invades decidua in the uterus during pregnancy and are postulated to help in maternal immunotolerance of the fetus. Published results on the relation between HLA-G and HLA-E polymorphisms and unexplained recurrent spontaneous abortion (RSA) are, however, controversial. This study was initiated in order to investigate whether HLA-G (G* 0103, G* 0104 and G0105N) and HLA-E (E* 0101 and E* 0103) polymorphisms are associated with risk of RSA in Palestinian women. Forty women with≥ 2 first trimester unexplained RSAs and 40 age-matched fertile women were genotyped for HLA-G and HLA-E polymorphisms by PCR-RFLP technique.
|Published in||International Journal of Reproduction, Contraception, Obstetrics and Gynecology|
|Series||Volume: 2, Number: 3|
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