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http://hdl.handle.net/20.500.12358/25295
TitleThe relationship between gene polymorphisms of coagulation factors II, V and XI and risk of recurrent pregnancy loss in Palestine
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Abstract

This retrospective case-control study was carried out in order to investigate the association between Factor II (G20210A), Factor V (G1691A, H1299R, Y1702C) and Factor XI (rs3756008 A> T) gene polymorphisms and recurrent pregnancy loss (RPL) in a group of Palestinian women residing in Gaza strip. A total of 400 females, 200 RPL patients and 200 women without previous history of RPL, aged 20 to 35 years were included in the study. Factor V (G1691A) and Factor II (G20210A) polymorphisms were analyzed by allelespecific PCR whereas, Factor V (H1299R, Y1702C) and Factor XI (rs3756008 A> T) gene polymorphisms were screened by PCR-RFLP. No statistically significant difference existed between RPL cases and controls in terms of the allelic and genotypic distribution of Factor II (G20210A), Factor V (Y1702C) or Factor XI (rs3756008 A> T). On the other hand, the minor allele of the two Factor V gene polymorphisms (G1691A and H1299R) independently showed statistically significant association with RPL. Factor V G1691 and H1299R polymorphisms may increase the risk for RPL in Gaza strip women, and should be screened for in cases suspected to have inherited thrombophilia.

Authors
Ashour, Mohammed J.
Sharif, Fadel A.
TypeJournal Article
Date2015
Published inInt J Med Med Sci
SeriesVolume: 3, Number: 3
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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