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http://hdl.handle.net/20.500.12358/25292
Title | Growth inhibition of Candida albicans and other medically important yeasts by vaginal contraceptive products |
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Untitled | |
Abstract |
The antifungal effects of two commercially available spermicidal gels (Conceptrol, produced by Ortho Pharmaceutical, Raritan, N.J., and Koromex, produced by Schmid Laboratories, Little Falls, N.J.) as well as pure nonoxynol-9 and boric acid (both components of vaginal contraceptive products) were tested against 50 clinical yeast isolates by the agar dilution method. The formulated products exerted comparable dose-dependent inhibitory effects against all yeasts tested. A 3-fold dilution of the formulated spermicidal products inhibited 90% of the yeast strains tested. To determine if the antifungal effect was due to the spermicidal detergent nonoxynol-9, this compound was tested for antifungal activity but was completely ineffective against Candida albicans in concentrations up to 10%. Boric acid, present in at least one of the products (Koromex), inhibited representative yeasts at a concentration of 0.4%. The … |
Authors | |
Type | Journal Article |
Date | 1990 |
Published in | Gynecologic and obstetric investigation |
Series | Volume: 29, Number: 1 |
Publisher | Karger Publishers |
Citation | |
Item link | Item Link |
License | ![]() |
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