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http://hdl.handle.net/20.500.12358/25239
TitleCommon Interleukin-18 Gene Polymorphisms in Women with Recurrent Spontaneous Abortion in Gaza Strip-Palestine
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Abstract

Accepted: 12 Dec 2014 Background: This work was carried out in order to investigate the association between Interleukin-18 (IL-18) gene SNPs (+ 105A> C," rs549908";-137 G> C," rs187238";-607 C> A," rs1946518"; and-656 G> T," rs1946519") and RSA among Palestinian women residing in Gaza Strip. Methods: In this case-control study, samples from 200 women (100 suffering from RSA and 100 control) were examined. All participants were genotyped for IL-18 SNPs:-137 G> C,-607 C> A,+ 105A> C, and-656 G> T. Allele specific polymerase chain reaction (AS-PCR) was used to detect IL-18-137 G> C and-607 C> A SNPs whereas, restriction fragment length polymorphism (RFLP-PCR) method was used for genotyping IL-18+ 105A> C and-656 G> T polymorphisms. Results: The results revealed that there is no significant association between the allele/genotype frequencies of the investigated IL-18 SNPs and RSA in the study population. Though not significant, the two groups showed remarkable differences in terms of allele/genotype frequencies of SNP-137 G> C. Conclusion: Among the examined IL-18 SNPs the promoter-137 G> C may be important in RSA in the investigated population.

Authors
Al-Ashi, Shadi F
Sharif, Fadel A.
TypeJournal Article
Date2014
Subjects
snp
gaza strip
interleukin-18
recurrent spontaneous abortion
polymorphism
SeriesVolume: 2, Number: 6
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  • Staff Publications- Faculty of Health Sciences [253]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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