Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12358/24420
Title | Substances from the medicinal mushroom Daedalea gibbosa inhibit kinase activity of native and T315I mutated Bcr-Abl |
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Abstract |
Human chronic myelogenous leukemia (CML) is a malignancy of pluripotent hematopoietic cells characterized by a distinctive cytogenetic abnormality resulting in the creation of a p210 Bcr-Abl fusion protein with abnormal tyrosine kinase activity. Recently, a selective Abl kinase inhibitor, Imatinib mesylate, was introduced as a first line therapy for CML. Despite the initial response, CML patients develop a resistantance to Imatinib, which is mediated mainly by point mutations within the Abl protein. Herein, we describe the identification of mycelium organic extracts of Daedalea gibbosa with selective anti-proliferating and apoptosis-inducing activities against K562 cells and other laboratory model of CML. Using activity-guided purification, we isolated an active fraction, F6, which inhibits in vitro kinase activity of recombinant Abl. The active fraction significantly inhibits the autophosphorylation of native and mutated Bcr … |
Type | Journal Article |
Date | 2008 |
Published in | International journal of oncology |
Series | Volume: 32, Number: 6 |
Publisher | Spandidos Publications |
Citation | |
Item link | Item Link |
License | ![]() |
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Files in this item | ||
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Yassin, Maged M._10.pdf | 240.5Kb |