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http://hdl.handle.net/20.500.12358/24405
Title | Bioactive properties of iron-containing carbon monoxide-releasing molecules |
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Untitled | |
Abstract |
Carbon monoxide-releasing molecules (CO-RMs) are compounds capable of delivering controlled amounts of CO within a cellular environment. Ruthenium-based carbonyls [tricarbonyldichloro ruthenium(II) dimer and tricarbonylchloro-(glycinato)ruthenium(II)] and boronacorbonates (sodium boranocarbonate) have been shown to promote vasodilatory, cardioprotective, and anti-inflammatory activities in a variety of experimental models. Here, we extend our previous studies by showing that η-4-(4-bromo-6-methyl-2-pyrone)tricarbonyl iron (0) (CORM-F3), an irontricarbonyl complex that contains a 2-pyrone motif, liberates CO in vitro and exerts pharmacological actions that are typical of CO gas. Specifically, CORM-F3 caused vasorelaxation in isolated aortic rings and inhibited the inflammatory response (e.g., nitrite production) of RAW264.7 macrophages stimulated with endotoxin in a dose-dependent fashion. By … |
Type | Journal Article |
Date | 2006 |
Published in | Journal of Pharmacology and Experimental Therapeutics |
Series | Volume: 318, Number: 1 |
Publisher | American Society for Pharmacology and Experimental Therapeutics |
Citation | |
Item link | Item Link |
License | ![]() |
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Hammad, Jehad_2.pdf | 405.5Kb |