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http://hdl.handle.net/20.500.12358/24372
TitleNMDA antagonists increase recovery of evoked potentials from slices of rat olfactory cortex after anoxia
Untitled
Abstract

1 The role of glutamate in producing tissue damage during cerebral anoxia was investigated in brain slices using antagonists to the NMDA and AMPA receptor types. 2 Tissue function was assessed by field recordings of the synaptically evoked potentials elicited by stimulating the main afferent input to the olfactory cortex, the lateral olfactory tract. Anoxia was produced by bathing the slice in glucose‐free solution equilibrated with 95% N2/5% CO2. 3 The amount of recovery of the evoked potential was inversely dependent on the period of anoxia and temperature: at 24° C, 15 min of anoxia followed by reoxygenation produced a 14.6±4.1% recovery whereas there was no recovery at 35° C. 4 Dizocilpine and ketamine had no effect on synaptic transmission in oxygenated media but following anoxia they produced an increased recovery of the responses: from 14.6±4.1% to 48.3±7.8% for dizocilpine (10 μm) and 21.6±7 …

Authors
Yassin, Maged M.
Scholfield, CN
TypeJournal Article
Date1994
Subjects
anoxia
rat
olfactory cortex
dizocilpine
glutamate
nmda
brain
neuroprotection
Published inBritish journal of pharmacology
SeriesVolume: 111, Number: 4
PublisherBlackwell Publishing Ltd
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  • Staff Publications- Faculty of Medicine [149]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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