Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12358/24360
Title | HLA-DQ2 and-DQ8 haplotypes frequency and diagnostic utility in celiac disease patients of Gaza strip, Palestine |
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Untitled | |
Abstract |
Purpose Celiac disease (CD) diagnosis can be established by serological and small bowel biopsy (SBB), while absence of HLA-DQ2 and -DQ8 haplotypes excludes the disease. The present study aims at evaluating the diagnosis of a representative sample of pediatric and adult CD patients of Gaza strip in light of DQ2 and DQ8 haplotypes expression. Methods Unrelated CD patients (n = 101) and matched healthy controls (n = 97) were genotyped for DQA1*05, DQB1*02 and DQB1*03:02 alleles by allele-specific real-time PCR. The diagnosis was re-evaluated according to the patient laboratory tests and HLA-DQ genotype. Results The diagnosis of 35 patients who have been managed for CD could not be confirmed. Twenty-five of them were diagnosed upon their clinical presentation only. The remaining were either … |
Type | Journal Article |
Date | 2017 |
Published in | Autoimmunity Highlights |
Series | Volume: 8, Number: 1 |
Publisher | Springer International Publishing |
Citation | |
Item link | Item Link |
License | ![]() |
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Files in this item | ||
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Yassin, Maged M._60.pdf | 140.4Kb |