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http://hdl.handle.net/20.500.12358/24313
TitleAblation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes
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Abstract

Background: Ceramide synthase 1 catalyzes the synthesis of C18 ceramide and is mainly expressed in neurons of the brain. Results: Ablation of Ceramide Synthase 1 decreases ganglioside levels and expression of oligodendrocytic Myelin Associated Glycoprotein in motor impaired mice. Conclusion: CerS1-derived C18-gangliosides are essential for cerebellar development and neurodevelopmentally-regulated behavior in mice. Significance: Neuronal gangliosides regulate expression of Myelin associated Glycoprotein in oligodendrocytes. Abstract Ceramide synthase 1 (CerS1) catalyzes the synthesis of C18 ceramide and is mainly expressed in the brain. Custom-made antibodies to a peptide from the C-terminal region of the mouse CerS1 protein yielded specific immuno-signals in neurons and no other cell types of wild type brain, but did not detect the CerS1 protein in CerS1 deficient mouse brains. To elucidate …

Authors
Ginkel, Christina
Hartmann, Dieter
Dorp, Katharina Vom
Zlomuzica, Armin
Farwanah, Hany
Eckhardt, Matthias
Sandhoff, Roger
Degen, Joachim
Rabionet, Mariona
Dere, Ekrem
Dörmann, Peter
Sandhoff, Konrad
Willecke, Klaus
TypeJournal Article
Date2012
Subjects
sphingolipid
gene knockout
myelin associated glycoprotein
ceramide synthase
ganglioside
neurodegeneration
transgenic mice
Published inJournal of Biological Chemistry
SeriesVolume: 287, Number: 50
PublisherAmerican Society for Biochemistry and Molecular Biology
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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