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http://hdl.handle.net/20.500.12358/24133
TitleStructural Chromosome Abnormality in Recurrent Pregnancy Loss in Gaza Strip: First Experience
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Abstract

Objective This study was conducted in order to evaluate the type and frequency of structural chromosome abnormality in phenotypically normal couples suffering from recurrent pregnancy loss. Subjects and Methods: Cytogenetic analysis was carried out for 50 Palestinian couples (100 cases), residing in Gaza Strip, who presented with repeated abortions at the Genetics Diagnosis Laboratory of the Islamic University in Gaza, Palestine. Results: It was found that 5 (10.0%) couples showed a chromosomal abnormality in one of the partners. Two reciprocal translocations, one inversion, one deletion, and one derivative chromosome were identified. The reciprocal translocations and the inversion constitute novel structural abnormalities that have not reported before. The deletion case also was not recorded before in recurrent abortion. Additionally, nine (18.0%) chromosome variants were encountered in the study population. Conclusion: These results confirm the notion that chromosomal abnormality is an important cause of recurrent abortion, and chromosomal analysis should be seriously considered by physicians working in Gaza strip as an etiological factor in couples suffering from recurrent abortions. Key Words: Recurrent pregnancy loss, Cytogenetic, Chromosomal abnormality

Authors
Sharif, Fadel A.
TypeJournal Article
Date2012
LanguageEnglish
Subjects
cytogenetic
recurrent pregnancy loss
chromosomal abnormality
Published inIUG Journal for Natural and Engineering Studies
SeriesVolume: 20, Number: 1
Publisherالجامعة الإسلامية - غزة
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  • Staff Publications- Faculty of Health Sciences [192]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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