مقارنة مستوي الاجسام المضادة ضد بروتين السيترولين 2 مع عامل الروماتزم في تشخيص التهاب المفاصل الروماتزمي في قطاع غزة

Abstract

Objectives: To compare the diagnostic value and clinical utility of Anti cyclic citrullinated protein 2 antibody (ACCP2A) with IgM rheumatoid factor (IgM RF) in patients with rheumatoid arthritis (RA). Methods: In a cross sectional study, we determined titers of these markers in 67 arthritis patients and 75 healthy controls by enzyme linked immuno-sorbent assay (ELISA). C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were also assayed as inflammatory parameters for all subjects. All clinical features were investigated by a rheumatologist and questionnaire interviews. And all results were analyzed by SPSS version "15". Results: sensitivity was higher for IgM RF (85%) than ACCP2A (56%) but specificity was higher for ACCP2A (99%) than IgM RF (69%). When the two antibodies were used together, sensitivity and specificity reached 88% and 100%. A correlation with extra articular manifestations, severity of erosions and CRP was observed for both tests.