Please use this identifier to cite or link to this item:
|Title||EVALUATION OF THE EFFICACY OF HEPATITIS B VACCINE IN DIFFERENT AGE GROUPS OF IMMUNIZED CHILDREN IN GAZA STRIP|
The objective of this study was to evaluate the long-term efficacy of hepatitis B virus immunization program in Gaza strip on preventing hepatitis B virus"HBV" infection, and assesses its impact on the incidence of hepatitis B in children. The participants in this study were 180 children; 90 males and 90 females categorized into three age groups (2 – 5 y), (6 – 8 y) and (9 –11 y). Serum samples from each participant were tested for the quantitative determination of anti-hepatitis B virus surface antigen (anti-HBs) antibody using microparticle enzyme immunoassay (MEIA) technology as well as immunochromatographic qualitative testing for hepatitis B surface antigen (HBsAg). The study showed that the efficacy of hepatitis B vaccine was 98.3%. HBsAg was not detected in any participant. The protective level for the (2 – 5 y) and (6 – 8 y) groups were 100% while the protective level for the (9 – 11 y) group was 95% (P ≤ 0.04). The study also showed that the efficacy of hepatitis B vaccine was statistically significant among the three age groups (P < 0.04), especially between (2 – 5 y) group and (9 – 11 y) group, as well as between (2 – 5 y) group and (6 – 8 y). The results of this study revealed that there was no significant difference between males and females for hepatitis B vaccine efficacy (P > 0.05). We concluded that the hepatitis B vaccine efficacy is high in immunocompetent population and a booster dose is not necessary at least in the studied age groups, due to the existence of an anamnestic response.
|Published in||IUG Journal for Natural Studies|
|Series||Volume: 14, Number: 2|
|Publisher||الجامعة الإسلامية - غزة|
|Files in this item|