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http://hdl.handle.net/20.500.12358/24100
TitleCombined Caffeine and Cisplatin Treatment Induces Synergistic Cytotoxicity in Hela Cell Line
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Abstract

Cisplatin is a common alkylating anticancer agent that has been used to treat several cancers. However, the efficiency of cisplatin treatment is limited due to the severe side effects and the resistance to the drug, which eventually results in treatment failure. Caffeine is a natural ingredient contained in many food sources. Caffeine has been shown to induce cell cycle arrest and apoptosis in different cancer cell types. The effect of caffeine on cisplatin treatment on cervical cancer cells is not well known. Here we examined the combined effect of caffeine and cisplatin in human Hela cells. The cancer cells were exposed to different concentrations of caffeine and cisplatin and IC50’s were determined by MTT assay. Cell number and viability were measured by cell counting and trypan blue assays. Data obtained show that, caffeine treatment enhances the anti-proliferation effect of cisplatin and lowered the IC50 of cisplatin from 8.93 µM to be 2.75 µM. These results suggest that caffeine-assisted chemotherapy is useful for cervical cancer treatment.

Authors
Abu Tayem, Husam Eddeen M.
Aliwaini, Saeb H.
Aljoujou, Salsabeel H.
Al-Qatati, Abeer S.
Dawas, Sanabel A.
TypeJournal Article
Date2017
LanguageEnglish
Subjects
cervical cancer
cisplatin
caffeine
Published inIUG Journal of Natural Studies: (Special Issue) The Sixth International Conference on Science & Development � 14-15 march 2017
SeriesVolume: 25, Number: 2
Publisherالجامعة الإسلامية - غزة
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  • Staff Publications- Faculty of Science [907]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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