Evaluation of some Physiological and Biochemical Parameters of Healthy Women Administrated Oral Contraceptive Pills in Gaza City

Abstract

Aim: To evaluate some physiological and biochemical parameters of healthy women who administrated oral contraceptive (OC) pills for at least three continuous menstruation in Gaza City. Subjects and Methodology: The study design was a case control. The experimental sample size was 80 healthy women aged 20-35 years from the Swidey Clinic who had taken OC pills for at least for three continuous cycles. The control sample was healthy married women who were not going on OC before and match the experimental sample in age and residence. The study questionnaire included issues about the following information: age, body mass index (BMI), nature (regular/ irregular) of menstrual cycle (MC), frequency of bleeding and increasing appetite, blood pressure and so on. Blood parameters analysis of the study population included complete blood count (CBC), C-reactive protein (CRP), high density lipoproteins cholesterol (HDL-C), low density lipoproteins cholesterol (LDL-C), total cholesterol (TC), and triacylglycerol (TAG). Leptin was carried out using a commercially available diagnostic system test kits. SPSS version 13 system was used to analyze obtained data. Results: Complete blood count (CBC) analysis showed significant differences among the study population with respect to white blood cells count (WBC), lymphocytes (Lymp), Granulocytes (Gran), mean cell hemoglobin (Mch), and red cell distribution width (RDW). For other CBC parameters no significant differences among the population were found. The results also showed statistically significant differences among study population with respect to nature of menstrual cycle (MC, p= 0.024), increasing appetite (p= 0.002), BMI (p= 0.015), TC (p= 000), LDL-C (p= 0.002), CRP (p= 0.034), and Leptin (p= 0.003). In contrast, the results showed no statistical differences among the study population with respect to systolic blood pressure (SBp, p= 0.139), diastolic blood pressure ( DBp, p= 0.382), HDL-c (p= 0.148), and TAG (p= 0.218), Moreover, the results showed a high strong correlation between BMI and leptin ( p = 0.000) among the study population. Key words: Oral contraceptive, Healthy women, biochemical parameters, Gaza city.