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|Title||Thyroid and Glutamic Acid Decarboxylase Autoantibodies Status of Type 1 Diabetes Mellitus Subjects in Gaza|
|Title in Arabic||الاجسام المضادة الذاتية للغدة الدرقية و لحمض الجلوتاميك منزوع الكاربوكسيل لدى مرضى السكر النوع الاول في غزة|
Autoimmune diseases are manifested in a wide-ranging at all the world and always concomitant with each other. Autoimmune diseases are in most cases characterized by the presenceof specific autoantibodies. Diabetes Mellitus type1 as the most common autoimmune disease often associated with other autoimmune diseases. Thyroid autoimmune disease is the most frequently concomitant disease to T1DM. Aims of the study: to evaluate the existence of anti-Glutamic acid decarboxylase antibodies (GAD)in T1DM patients, and to estimate anti-thyroglobulin antibodies (TG) and anti-Peroxidase antibodies (TPO) as markers of thyroid autoimmune disease in T1DM patients. The study was also interested to assess the association between thyroid antibodies (anti-TG, and anti-TPO) Abs and anti-GAD Abs and assess thyroid diseases among T1DM by tested thyroid releasing hormone (TSH) and free thyroxin (FT4). Methodology: the sample size was 80 patients, recorded in Gaza city as T1DM patients (38 males and 42 females) aged from 1 - 25 years. Anti-TPO, anti-TG, and anti-GAD antibodies were determined by ELISA technique and (FT4, TSH) were determined by Axsym. Results: Anti-GAD Abs were positive in 36(45%) of patients, (61.1% male and 38.9% females). Anti-TPO Abs were positive in 44 (55%) were (40.9% males and 59.1% females). Anti-TG Abs were observed in 46 (57.5%) patients (39.1% males, and 60.9% females), TSH were high in 7 (8.7%) patients while FT4 were high in 4 (5.0%) patients. Found a high significant correlation between anti-GAD Abs and anti-TG Abs (P= 0.001), equivalent correlation was found between anti-GAD Abs and anti-TPO Abs (P=0.001) and highly significant correlation were existed between anti-GAD and both anti-(TPO, TG) Abs was significant (P= 0.018) where the percentage of positive anti-GAD Abs and both anti-Thyroids antibodies was 77.8%. In addition the relation between anti-TPO and anti-TG Abs also highly significant (P=.000). Conclusion: strong relation was detected between T1DM and thyroid autoimmune markers which can predict the possibility to get thyroid diseases. The study concluded that anti-GAD Abs test could be used as confirmatory diagnostic test for T1DM patient, also anti-TG Abs anti-TPO Abs TSH, and FT4 could be considered as screening tests for all T1DM patients to investigate thyroid disease among them.
|Publisher||the islamic university|
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