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http://hdl.handle.net/20.500.12358/21910
TitleObestatin Level and some Biochemical Parameters in Type 2 Diabetic Women Attending Medical Relief Center in Gaza Governorate
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Abstract

Background: Obestatin is a novel 23-amino acid peptide derived from the mammalian prepro-ghrelin polypeptide. Recent studies demonstrated that obestatin is a metabolic hormone associated with type 2 diabetes. Therefore, assessment the status of obestatin and clarifying such association in diabetes could constitute a promising therapy of the disease. Objective: To asses obestatin level and some biochemical parameters among type 2 diabetic women attending Mediacl Relief Center in Gaza. Materials and Methods: This case-control study comprised 64 type 2 diabetic women and 64 healthy non diabetic women. Questionnaire interview was applied. Serum obestatin was measured by ELISA. Serum glucose, cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), urea and creatinine were determined. Blood HbA1c was also measured. Data were computer analyzed using SPSS version 18.0. Results: The mean ages of controls and cases were 52.7±8.9 and 52.9±8.3 years. Type 2 diabetes was found to be significantly associated with family history and diet. More than half of patients had diabetes since less than 5 years. The main self-reported complications among patients were neuropathy, retinopathy and cardiovascular disease. The longer the duration of diabetes, the higher the prevalence of self-reported complications. The mean level of serum obestatin was significantly lower in diabetic women compared to healthy non diabetic controls (3.4±0.8 ng/ml vs. 4.1±1.5 ng/ml, P=0.023).The mean HbA1c and glucose levels in cases were significantly higher than that in controls (6.4±0.9 and 190.7±86.7 vs 4.7±0.6 and 101.6±21.0) with P=0.000. The Pearson correlation test showed negative significant correlations between obestatin levels and HbA1c and glucose (r=-0.320, P=0.009 and r=-0.469, P=0.000 respectively). The average level of triglycerides was significantly increased in diabetic women (183.3±80.0mg/dl) compared to controls (122.4±42.9 mg/dl) with P=0.000. On the other hand, HDL-C was significantly lower in cases (40.7±11.2vs. 47.2±12.0mg/dl, % difference=14.8 and t=2.228, P=0.030). The Pearson correlation test showed negative significant correlations between obestatin levels and triglycerides levels (r=-0.275, P=0.026). Conclusions: Serum obestatin was significantly lower in diabetic women compared to healthy non diabetic women. There were negative significant associations between obestatin levels with HbA1c, glucose and triglycerides levels.

Authors
Hamam, Mona M.
Supervisors
Yassin, Maged M.
Typeرسالة ماجستير
Date2013
LanguageEnglish
Publisherالجامعة الإسلامية - غزة
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  • PhD and MSc Theses- Faculty of Science [445]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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