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http://hdl.handle.net/20.500.12358/21901
TitleAssessment of Apolipoprotein C- III as A predictor of Cardiovascular Diseases among Type 2 Diabetic Men in Gaza Strip
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Abstract

Background: Diabetes mellitus is one of the most important risk factors for cardiovascular diseases. Apolipoprotein C-III (apo C-III) is a multifunctional protein that not only regulates the metabolism of triacylglycerols but also an important regulator of endothelial function. In the presence of hyperlipidema, apo C-III exerts proinflammatory effects on both monocytes and endothelial cells that are important for transendothelial migration of monocytes into the vessels’ intima and development of atherosclerosis. Objectives: To investigate the prognostic value of plasma apo C-III concentrations for cardiovascular complication among Type 2 Diabetes mellitus (T2DM) patients in Gaza strip. Subjects and methods: This study is a case-control study; a total of 89 male of T2DM were evaluated and classified into two groups according to heart disease [52 of T2DM patients without heart disease and 37 with heart disease] and equal number of normal subjects (n=89) were run in parallel with each group as a control. Apo C-III and apoA1 were measured using immunoturbidimetric methods. Glucose, creatine kinase (CPK), creatine kinase MB (CK-MB), aspartate aminotransferase (AST), Lactate aminotransferase (LDH), cholesterol, triacylglycerols (T.G) and, HDL-C were measured using colorimetric and kinetic method and low density lipoprotein (LDL-C) was calculated using the empirical relationship of Friedewald. Results: The concentration of apo C-III, glucose, LDL, cholesterol, triacylglycerols, apoA1, LDH, AST, CPK and, CK-MB were significantly increased among T2DM patients (P<0.05). There was positive correlation between apo C-III and plasma triacylglycerols in T2DM patients compared with control (r=0.755, p=<0.001 and r=0.426, p=0.001 respectively). Also, there were positive correlation between apo C-III and glucose, cholesterols, AST and apoA1 among T2DM patients (r=0.238,p=0.012, r=0.340,p=0.001, r=0.237,p=0.013, r=0.242, p=0.011 respectively). There was statistically significant difference between apo C-III (p<0.05) in the two cases groups of T2DM (with/without heart disease) and between the obese and non-obese T2DM patients. There was significant difference between apo C-III and insulin treatment (p<0.05), while no significant difference was found between lipid-lowering drug and apo C-III. Conclusion: High level of Apo C-III and low level of apoA1 concentration in plasma, independently of fasting triacylglycerols and other traditional risk factors, predicts cardiovascular mortality among T2DM patients.

Authors
Awad, Ferial S.
Supervisors
Masad, Atef A.
Typeرسالة ماجستير
Date2013
LanguageEnglish
Publisherالجامعة الإسلامية - غزة
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  • PhD and MSc Theses- Faculty of Science [445]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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