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|Title||Islet Amyloid and Selected Trace Elements among Type 2 Diabetes Mellitus Patients in Gaza City|
|Title in Arabic||هرمون الاميلين و بعض العناصر النادرة في مرضى السكري (النوع الثاني) في مدينة غزة|
Background: Diabetes mellitus is one of the most worldwide spread chronic diseases, and its complications are very serious if it is untreated. Amyloid deposits derived from a peptide called amylin are found in the pancreas in the vast majority of cases of type 2 diabetes mellitus (T2DM). Free Fe and Cu ions are the most redox-active metals in mammalian tissues, where they may contribute to tissue damage by generation of reactive oxygen species (ROS) such as hydroxyl radicals. It has not been established if altered transition metal metabolism, play a role in the forms of heart disease that complicate the major classes of diabetes or if altered transition metal ion metabolism plays a role in islet amyloid or β-cell toxicity. The hypothesis that T2DM individuals have high levels of islet amyloid polypeptide (amylin) and impaired levels of trace elements which may be involved in the toxicity of the amylin peptide among T2DM patients have been investigated. Aim of the study: To investigate the concentration of selected trace elements and islet amyloid level among T2DM in comparison with control. Materials and methods: For this project, ELISA (Enzyme Linked Immunosorbent Assay) technique was used to detect amylin level. Blood sugar and metal ion level such as Copper, Zinc, Iron, and Magnesium were detected by colorimetric methods in the serum of T2DM patients and control. Variations in the concentration of trace elements and amylin levels in T2DM and non-diabetic control were statistically analysed and evaluated. SPSS software was used to analyse obtained data. RESULTS: There was statistically significant difference between patients and controls in the blood sugar level, Zn, Mg and amylin (p<0.05) with negative correlation for Zn and Mg and positive correlation for amylin. There was statistically significant differences for patients who suffer from diabetic coma for blood sugar, and Zn (p<0.05). Patients with neuropathy have statistical significant value with the level of Zn (p <0.05), While, Copper and iron didn't show any difference (p>0.05). There was significant negative correlation between blood sugar and Zn (p=0.006) also there were significant positive correlation between Cu and both of Zn (p=0.026) and Mg (p=0.014). Conclusion: There were significant differences between healthy group and diabetic group with regard to the level of trace elements (Zn, Mg) and amylin hormone. Diet and food restriction was a helpful tool in managing and controlling of diabetes and then minimizing the risk of diabetes complications. Blood sugar level, amylin hormone and Fe were influenced with age while, Fe was only influenced with sex. Mg level was influenced with smoking in patient's group. Blood sugar and Zn levels were altered in diabetic patients with diabetic coma. In diabetic neuropathy patient's Zn level was significantly low compared with patients who don't have neuropathy.
|Publisher||the islamic university|
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