Resistin Hormone Level among Type 2 Diabetic Patients in Gaza Governorate

Abstract

Objective: To assess resistin hormone among type 2 males diabetic patients (T2DP) in Gaza Governorate. Subjects and methods: It is a case control study included 90 males subjects, 45 of them were T2DP and the rest of them were 45 healthy non diabetic controls that matched each other in ages, sex and residence. A questionnaire interview was used as a tool of study. Serum resistin, glucose, insulin, cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and homeostasis model assessment of insulin resistance (HOMA –IR) were determined. Data were analyzed using SPSS version 18.0. Results: The mean ages of controls and cases were 50.93±5.74 and 51.64±4.76 years, respectively. Diabetes mellitus was more prevalent among individuals with family history of diabetes. Most of studied patients had had diabetes since less than 5 years. The self-reported complications among diabetic patients were hypertension, numbness in toes, heart diseases and retinopathy. Smoking or Physical activity had no association with serum resistin level (P>0.05). The BMI hadn’t also any possible correlation with serum resistin level. The mean level of serum resistin had not any significant difference between diabetic patients and controls (P>0.05). Moreover the mean serum glucose levels in cases were significantly higher than that in controls (180.78±76.3 mg/dl Vs 90.89±12.88 mg/dl) (P=0.000) with no any significant correlation between resistin with glucose. The mean serum insulin an insulin resistant levels in cases were significantly higher than that in controls (P>0.05). The average levels of cholesterol, triglycerides, HDL-C and LDL-C had not significantly difference in cases compared to controls. The Pearson correlation test revealed negative significant correlation between resistin and triglyceride or cholesterol (P<0.05). Conclusion: The preliminary study revealed that Serum resistin hasn’t any significant relation with type 2 diabetes mellitus or insulin resistant.