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|Title||Prevalence and Risk Factors of Hepatitis B and C Viruses among Haemodialysis Patients in Gaza Strip, Palestine|
End stage renal disease patients (ESRD) on maintenance haemodialysis (HD) are at high risk of acquiring hepatitis B and C viruses (HBV, HCV) infection. The aim of this study is to investigate the prevalence of HBV and HCV infection and to determine risk factors associated with their transmission among HD patients in Gaza Strip. During the study all patients attending the four HD centers in Gaza Strip (246 patients) were tested for the presence of hepatitis B surface antigen (HBsAg) by using the second generation enzyme immunoassay and anti-HCV by using the third generation enzyme immunoassay. HCV RNA was detected using reverse transcriptase polymerase chain reaction (RT-PCR). A questionnaire that included possible risk factors was completed by the researcher via patient interview to insure proper data collection. The overall prevalence of HBV among the four HD centers was 8.1% compared with a prevalence rate of 2.3% among healthy blood donors inGazaaccording to the latest report of the Palestinian Ministry of Health (MOH). The main risk factors were HD center (p=0.05), history of blood transfusion (p<0.01) and treatment abroad (p=0.01). The overall prevalence of HCV among the four HD centers was 22% compared with a prevalence rate of 0.2% among healthy blood donors inGazaaccording to the latest report of MOH. The main risk factors were HD center (p<0.01), time duration on HD (p<0.01), history of blood transfusion (p<0.01), treatment abroad (p<0.01) and history of blood transfusion abroad (p<0.01). The much higher prevalence of Hepatitis viruses among HD patients compared to normal population of Gaza Strip indicates a causative relation between HD and hepatitis viruses transmission. Therefore extremely careful observation of preventive infection control measures is essential to limit Hepatitis viruses' transmission in HD centers.
|Publisher||the islamic university|
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