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http://hdl.handle.net/20.500.12358/21828
TitleEvaluation of the Efficacy of Hepatitis B Vaccine in Different Age Groups of Immunized Children in Gaza Strip
Title in Arabicتقييم فعالية مطعوم التهاب الكبد الوبائيb في فئات عمرية مختلفة من الاطفال المحصنين في قطاع غزة
Abstract

The objective of this study is to evaluate the long-term efficacy of infant hepatitis B immunization program in Gaza strip on preventing hepatitis B virus infection, and assess its impact on the incidence of hepatitis B in children. The participants in this study were 180 children, 90 males and 90 females categorized into three age groups (2 - 5y), (6 - 8y) and (9 -11y). Serum samples for each participant were tested for the quantitative determination of anti-HBs antibody using microparticle enzyme immunoassay (MEIA) technology as well as immunochromatographic qualitative testing for HBs Ag. The study showed that the efficacy of hepatitis B vaccine is 98.3% . HBs Ag was not detected in any participant. The protective rates for the (2 - 5y) and (6 - 8y) groups were 100% while the protective rate for the (9 - 11y) group was 95% (P 0.04). Also the study showed that the efficacy of hepatitis B vaccine was statistically significant among the three age groups (P < 0.04), especially between (2 - 5y) group and (9 - 11y) group, also between (2 - 5y) group and (6 - 8y). The results of this study revealed that there was no significant difference between males and females for hepatitis B vaccine efficacy (P > 0.05). We concluded that the hepatitis B vaccine efficacy is high in immunocomptent population and a booster dose is not necessary at least in the stodied age groups, due to the existence of an anamenstic response.

Authors
Elian, Faten Mohammad
Supervisors
Shubair, Mohammad E.
Typeرسالة ماجستير
Date2006
LanguageEnglish
Publisherthe islamic university
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  • PhD and MSc Theses- Faculty of Science [445]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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