Assessment of Liver and Kidney Functions in Patients Receiving Antipsychotic and Antiepileptic Drugs in Gaza

Abstract

Background: many drugs affect liver and kidney functions, among these, drugs used to treat psychotic patients such as chlorpromazine (CPZ) which is used to treat schizophrenia and Trihexyphenidyl- hydrochloride ( T.H.P) which is used to treat side effect of antipsychotic medication, another drug which is used to treat epilepsy is valproic acid (VPA) which may affect the liver and kidney functions. Objective: This study aims at assessing liver and kidney functions in patients receiving antipsychotic and antiepileptic drugs for more than one year. Materials and methods: The present study is a case control study comprised of 220 subjects including 110 psychiatric and epileptic patients from Mental health clinics in Gaza and 110 healthy people as a control group. Experimental work was done by using five ml blood were collected from each subject into vacutainer plain tubes. Serum Gamma glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), Serum urea, creatinine, uric acid, alkaline phosphatase (ALP), serum total and direct bilirubin ( TB, DB) were assayed biochemically using biosystem autoanalyze. Spss was used to analyze obtained data. Results: The liver and kidney function tests among epileptic patients receiving Valproic Acid (VPA) showed high statistically significant differences between cases and control groups with respect to AST test. While liver and kidney function tests in psychiatric patients suffered from schizophrenia receiving chlorpromazine (CPZ) with Trihexyphenidyl hydrochloride (T.H.P) showed, significant differences between cases and control group in relation to AST, ALP, GGT, DB, creatinine and uric acid tests.