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|Title||Risk Factors Associated with Coronary Artery Disease in Gaza|
Coronary Artery Disease (CAD) remains the first killer and common silent disease in the world. The lipid profile plays the essential role in CAD development via atherogenesis process by depositing inside coronary arteries wall with lipid oxidation, which leads to artery narrowing then blockage. Recent studies showed inverse association between serum bilirubin and CAD development, although it involves endogenous anti-oxidant byproduct as HDL role. Our study aims to estimate the association of lipid profile, other risk factors and serum bilirubin with CAD development. Blood samples were taken from cross-sectional sample (n=94) of CAD inpatients (68 males and 26 females) recorded at the period of 1/6/2008 to 16/8/2008 at El-shefaa hospitalof Gaza. The patient history of age, sex, BMI, diabetic, hypertension, smoking, physical activity, stress, working and family history were collected by questionnaire, hospital administration and nursing data in coordination with the Department Physicians. The lipid profile and serum Bilirubin were analyzed by spectrophotometer in the same hospital and private laboratory. SPSS version 15 was used as the tool for statistical analysis. Distribution of risk factor value of mean age was 57.3 (56 inmales and 60.5 year in females). The middle age group (46-65 year) was higher than other groups (P<0.001). The mean BMI of total CAD patients was 28.7 (27.4 in males and 31.9 kg/m2 in females) and females of normal weight group were higher than males (P=0.003). The mean cholesterol level >200mg/dl was 167 (166 in males and 177 mg/dl in females), and the distribution of high risk group was 24.5% (26.5% males and 29% female). The mean of triglyceride level >150mg/dl was 163 (170 in males and 164 mg/dl in females), and the distribution of high risk group was 41.5 % (47.1% males and 73.7% females), the males were higher than females (P<0.05). The mean of HDL level >40mg/dl was 35 (35 in males and 33 mg/dl in females) and the distribution of lowered group was 72.3% (70.6% males and 76.9% females). The calculated LDL level >160mg/dl was 100 (97 males and 108 mg/dl females) and the distribution of high risk group was 19.1% (20.6% males and 15.4% females), the high total and direct bilirubin concentration group was (91.5% and 84%). The CAD under risk total cholesterol to HDL ratio (>4:1) was 62.8 % (61.8% males and 65.4% females), CAD under risk LDL to HDL ratio (>3.2) was 39.3% (53.1% males and 20.4% females) and CAD under risk HDL to LDL ratio (<0.3) was 40.3% (61.4% males and 46% females). Distribution of risk factor value of hypertensive patients were 36.3% (35.3% males and 38.5% females), the diabetic was 38.3 % (33.8% males and 50% females), the diabetic female was higher than male. The nonphysical activity was 54 % (47.1% of male and 73% of female), sedentary or inactive was higher than weak and heavy activity and sedentary females were higher than males (P=0.001). The smoking patients were 44.7% (60.3% males and 3.8% females). The life stress patients were 30.9 % (26.5% males and 42.3% females), stress of female was higher than male (P=0.01). The workers were 60% (80.9% of male and 3.8% of female), distribution of workers were higher than non workers (P=0.03) and male workers were higher than female workers (P=0.001). The family history was 29 % (32.4% males and 19% females).
|Publisher||the islamic university|
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