• العربية
    • English
  • English 
    • العربية
    • English
  • Login
Home
Publisher PoliciesTerms of InterestHelp Videos
Submit Thesis
IntroductionIUGSpace Policies
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
  •   Home
  • Faculty of Science
  • PhD and MSc Theses- Faculty of Science
  • View Item
  •   Home
  • Faculty of Science
  • PhD and MSc Theses- Faculty of Science
  • View Item

Please use this identifier to cite or link to this item:

http://hdl.handle.net/20.500.12358/21744
TitleGenetic Causes of Male Infertility in Gaza Strip- Palestine: A Combined Cytogenetic and Y Chromosome Microdeletions Study
Untitled
Abstract

Infertility is an extraordinary public health problem, especially in our Arab world, affecting about 15% of couples seeking children. However, in 50% of these the male partner is responsible for infertility. Chromosomal anomalies and Y chromosome classical microdeletions in the azoospermia factor (AZF) regions are known to be associated with spermatogenic failure. In addition, partial AZFc deletions have been exposed to continuing intense debate on whether they cause spermatogenic failures or not. In the current study, 85 patients with primary male infertility were studied in order to explore the cytogenetic and molecular background of male infertility in Gaza Strip of Palestine. Of the 85 infertile males, 8 patients (9.4%) showed chromosomal anomalies in the form of Klinefelter's syndrome [4/8, 50%], 47,XY,+mar [1/8,12.5%], 46,XY,del(17)(q25) [1/8,12.5%], 45,XY, Robertsonian fusion (15;21) [1/8,12.5%], and one with chromosomal instability that showed multiple mosaic karyotypes (1/8,12.5%). No Y chromosome classical microdeletions could be detected in any of the 85 infertile men, suggesting that ethnic factors, genetic background, and Y chromosome haplogroups are key factors in such deletions. On the other hand, 6 gr/gr AZFc partial deletion cases (6/85, 7%) and one b1/b3 AZFc partial deletion pattern (1/85, 1.2%) were detected in the infertile group, while one gr/gr deletion was detected in the proven fertile controls (1/30, 3.3%). In conclusion, our study proves that cytogenetic analysis is mandatory in any diagnostic workup of infertile males. Moreover, our study shows that the incidence of Y chromosome microdeletions is rare in our population, suggesting that other genetic, epigenetic, nutritional and local factors may be responsible for idiopathic azoo/oligozoospermic in Gazian Palestinian population. In addition, we suggest that gr/gr deletions may not be associated with male infertility.

Authors
Shaqalaih, Ashraf Jaber
Supervisors
Sharif, Fadel A.
Typeرسالة ماجستير
Date2007
LanguageEnglish
Publisherthe islamic university
Citation
License
Collections
  • PhD and MSc Theses- Faculty of Science [445]
Files in this item
file_1.pdf813.6Kb
Thumbnail

The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

Contact Us | Send Feedback
 

 

Browse

All of IUGSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsSupervisorsThis CollectionBy Issue DateAuthorsTitlesSubjectsSupervisors

My Account

LoginRegister

Statistics

View Usage Statistics

The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

Contact Us | Send Feedback