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|Title||Efficacy of Diphtheria and Tetanus Vaccination in Gaza Strip|
|Title in Arabic||فعالية التطعيم ضد الدفتريا والتيتانوس في قطاع غزة|
Vaccination is a preventive strategy in fight against infectious diseases and it is one of the most effective weapons of health protection of the modern medicine. Hence, it is necessary to continuously monitor the efficacy of vaccination programs. This study focused on the evaluation of effectiveness and usefulness of vaccination against diphtheria and tetanus in different age groups in Gaza Strip. Blood samples were collected from 180 children below 12 years of age, 90 males and 90 females, children were classified into 3 age groups, (2-4y), (7-8y) and (11-12y). Diphtheria and tetanus antitoxins were measured in serum samples using Enzyme Linked Immunosorbent Assay (ELISA). The study showed that the efficacy of diphtheria and tetanus vaccination among children below 12 years in Gaza was 87.8% and 98.3%, respectively, with a significant difference in efficacy among age groups. The study showed also that the mean titer of antibodies varies significantly among age groups (0.239, 0.632 and 0.460 IU/ml for diphtheria) and (1.00, 2.62 and 1.20 IU/ml for tetanus). There was no significant difference between male and female in vaccine efficacy. This study indicates that vaccination against tetanus is highly effective while it is less effective for diphtheria. Antibody titers in the vaccinated group were relatively low for both diphtheria and tetanus, which means that vaccine gives a short term protection, antibody level and vaccine efficacy decline over time and there is a need for Td booster dose.
|Publisher||الجامعة الإسلامية - غزة|
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