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|Title||Some Biochemical and Hematological Alterations Associated with Lead Exposure in Gasoline Station Workers in Gaza Strip|
Although occupational lead exposure is one of the major public health problems, no previous published research was conducted on lead exposed gasoline station workers in Gaza Strip. This study aimed to identify risk factors associated with lead exposure and to determine biochemical and hematological parameters in leaded gasoline station workers in Gaza Strip. Method: A total 105 gasoline station workers from the Gaza Strip were asked to fill in a questionnaire on knowledge, attitudes, and practice towards lead, as well as associated toxicity symptoms. Out of the 105, seventy two workers gave blood sample for blood lead level and biochemical analysis and those were compared with 70 controls. Atomic absorption spectrometry was used to determine Blood lead level. Liver and kidney function were determined by Biosystem reagent kits. Cell dyne was used to measure complete blood count and sphygmomanometer for blood pressure. SPSS version 11.0 was employed for data analysis. Results: More than half of workers work more than 5 years in the gasoline station. None of them were previously tested for lead. Although the majority of the workers know that lead is an environmental pollutant and has adverse health impact, small number of them follow the protective measures. The most common self reported symptoms among workers were headache, fatigue, irritability and concentration difficulties, sleep disturbance, hypertension, nausea, constipation and dyspepsia. Neither workers attended training courses nor had health professional visited them. The mean Blood lead level (BLL) of the followed up workers was 11.4µg/dl compared to 5.3µg/dl for the controls.Lower BLLwas found in highly educated workers. Positive association was found between BLLs of the workers and work duration. The BLLs in workers who used gloves, respiratory mask or drank milk frequently were significantly lower than those who did not (8.6±4.9, 5.6±1.6 and 9.3±5.2µg/dl versus 13.1±6.0, 12.4±5.9 and 13.3±5.2µg/dl, respectively). The BLLs were significantly higher in workers reported irritability, headache, sleep disturbance, concentration difficulties, hypertension (12.4±5.4. 12.2±5.8, 14.1±5.8, 12.9±5.8, 13.3±6.4 µg/dl, respectively) and those who had not report such symptoms (9.2±5.6, 9.0±5.9, 8.9±5.0, 9.4±5.6, 8.1±2.9µg/dl, respectively). A statistically significant increase were found in BLL, hemoglobin, MCV, MCH, MCHC, Alanine Transaminase (ALT), Aspartate Transaminase (AST), Creatinine, systolic and diastolic blood pressure among workers (11.4±6.0µg/dl, 15.4±1.5g/dl, 86.7±5.1, 30.5±3.1, 35.2±2.7, 29.1±11.5U/L, 28.6±7.9U/L, 0.9±0.2mg/dl, 125.7±13.2mmHg and 84.6±9.9mmHg, respectively) compared to controls (5.3±1.0µg/dl, 14.5±0.8g/dl, 84.3±3.7, 28.6±1.6, 33.6±1.2, 23.9±9.7U/L, 24.7±3.6U/L, 0.7±0.1mg/dl, 120.4±3.8mmHg and 81.9±2.7mmHg, respectively). While a statistically significant decrease were found in red blood cells count, Platelets counts, alkaline phosphatase (ALP) and urea in workers (4.9±0.4X106, 249.4±58.2X103cell/µl, 179.3±42.6U/L and 27.1±11.6mg/dl, respectively) compared to controls (5.1±0.23X106, 281.5±56.5 X103cell/µl, 193.6±31.8U/L, 31.3±6.3mg/dl, respectively).
|Publisher||the islamic university|
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