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|Title||Assessment of Vitamin A, Zinc and Iron in Wasted Children Aged 6-24 Months Old Attending Ard El Insan Association Gaza-Center|
Background:Wasting is considered as one of the leading causes of morbidity and mortality in children in developing countries. Micronutrients are essential for healthy growth and development. Objective: To assess vitamin A, zinc and iron in wasted children aged 6-24 months old attending Ard El Insan Association, Gaza-Center. Materials and methods: This case control study comprised 98 wasted children and 98 healthy control children. WHO Anthro 2007 software was used to compute a nutritional status index for wasting. Questionnaire interview with mothers was used. Blood samples were drawn for determination of serum vitamin A, zinc, iron and complete blood count. Statistical analysis was performed using SPSS version 18.0. Results: The mean ages were 10.2±3.2 and 9.7±3.8 months for controls and cases, respectively. Fifty two percent and 54.1% of controls and cases were males whereas 48.0% and 45.9% were females. The birth weight showed significant decrease in cases compared to controls (2.9±0.8, Vs 3.1±0.6, P=0.030). Wasting was inversely associated with mother education (P=0.044), family income (P=0.000) and receiving nutritional help or donation at a regular basis (P=0.001). Wasting was also inversely related to exclusive breastfeeding in the first 6 months (P=0.010), discontinuation of breastfeeding before 12 months (P=0.021) and introducing of complementary food before 6 months (P=0.000). Wasting was less common with good child appetite (P=0.046). The mean levels of serum vitamin A, zinc and iron were significantly decreased in cases compared to controls (546.8±384.0, 68.5±196 and 88.3±34.5 Vs 702.5±487.9, 74.2±7.8 and 106.3±11.0 with P=0.014, 0.008 and 0.000, respectively). The total WBC counts was significantly increased in cases compared to controls (11.0±3.3 Vs 9.7±3.4, P=0.003) whereas RBC, HGB and HCT were significantly decreased (4.4±0.4, 9.8±0.9 and 30.4±2.5 Vs 4.6±0.4, 10.9±0.7 and 32.0±2.7 with P=0.009, 0.000 and 0.001, respectively). Also, MCH and MCHC were significantly decreased (22.3±2.1 and32.1±1.2 Vs 23.9±1.9 and 34.3±2.0 with P=0.000, respectively). Wasting was significantly associated with respiratory and gastrointestinal tracts infections (P=0.000). There was significant decreases in the mean levels of vitamin A in wasted children having respiratory and gastrointestinal infections compared to those who had not (385.5±286.3, 430.9±352.0 Vs674.3±468.7, 601.2±439.2 with P=0.000 and P=0.042, respectively). Serum levels of zinc was significantly lower in wasted children who had respiratory tract infection than in those who had not (62.6±16.3 Vs69.2±16.9 with P=0.038). The mean serum levels of iron was significantly lower in children who had gastrointestinal infections than in those who had not (79.76±28.43 Vs 93.89±37.11 with P=0.041). Conclusions: Vitamin A, zinc and iron micronutrients are protective agents of infections at least in wasted children.
|Publisher||the islamic university|
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