• العربية
    • English
  • English 
    • العربية
    • English
  • Login
Home
Publisher PoliciesTerms of InterestHelp Videos
Submit Thesis
IntroductionIUGSpace Policies
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
  •   Home
  • Faculty of Science
  • PhD and MSc Theses- Faculty of Science
  • View Item
  •   Home
  • Faculty of Science
  • PhD and MSc Theses- Faculty of Science
  • View Item

Please use this identifier to cite or link to this item:

http://hdl.handle.net/20.500.12358/21585
TitleCandidate Gene Polymorphisms and Risk of Type-2 Diabetes Mellitus in Gaza Strip
Title in Arabicالتعدد الشكلي لجينات ذات صلة بخطر الاصابة بمرض السكري من النوع الثاني في قطاع غزة
Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease that results from the interaction between multiple genetic and environmental factors. Genome-wide association studies revealed many T2DM-associated genetic polymorphisms in various populations. Among the genes polymorphisms that were strongly associated with diabetes are (PPARG rs1801282), (TCF7L2 rs7903146), (SLC30A8 rs13266634), (CDKAL1 rs10946398), and (KCNJ11 E23K). Objective: To investigate the association between (PPARG rs1801282), (TCF7L2 rs7903146), (SLC30A8 rs13266634), (CDKAL1 rs10946398), and (KCNJ11 E23K). genes polymorphisms and T2DM in the Gaza strip population. Methods: In this case-control study 100 T2DM male patients and 100 control men were examined. The two groups were genotyped for the five genes polymorphisms using restriction fragment length polymorphism-PCR (RFLP-PCR) technique. Body mass index (BMI), glycated hemoglobin (HbA1c), insulin (C-peptide), total cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were measured for all the study participants. The relation between the five genes polymorphisms, T2DM and the measured clinical parameters were statistically analyzed using appropriate tests. Results: Among the tested polymorphisms, significant association was evident only between KCNJ11 E23K polymorphism and T2DM (P = 0.03). The TCF7L2 "TT" genotype was significantly associated with increased HDL-C levels in both patients and controls (P values = 0.01 and 0.04, respectively). Moreover, the "TT" genotype proved to be significantly associated with lower plasma LDL-C in the patient group (P = 0.001). The SLC30A8 "TT" genotype showed a significant effect on BMI in the control subjects (P value = 0.01) and on lower HbA1c level in the patient group (P value = 0.02). There was a significant increase in the means of BMI, triglycerides and HbA1c in patients as compared to controls (P values = 0.00, 0.02, and 0.00, respectively). Conclusion: KCNJ11 E23K is significantly associated with T2DM in the Gaza strip population. The TCF7L2 "TT" genotype is significantly related to increased HDL-C level in the study population and to lower plasma LDL-C in the patients group. The SLC30A8 "TT" genotype is significantly correlated with BMI in the control group. The means of BMI, triglycerides and HbA1c are significantly increased in patients as compared to controls. The study recommends confirming the obtained results on a larger sample, and examining the association of other genes polymorphisms with T2DM in Gaza strip. Keywords: (PPARG), (TCF7L2), (SLC30A8), (CDKAL1),( KCNJ11 E23K), polymorphism ,type 2 diabetes mellitus, T2DM, Gaza strip.

Authors
Altallqa, Israa Omar
Supervisors
Sharif, Fadel A
Typeرسالة ماجستير
Date2017
LanguageEnglish
Publisherالجامعة الإسلامية - غزة
Citation
License
Collections
  • PhD and MSc Theses- Faculty of Science [445]
Files in this item
file_1.pdf2.680Mb
Thumbnail

The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

Contact Us | Send Feedback
 

 

Browse

All of IUGSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsSupervisorsThis CollectionBy Issue DateAuthorsTitlesSubjectsSupervisors

My Account

LoginRegister

Statistics

View Usage Statistics

The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

Contact Us | Send Feedback