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|Title||Long Term Toxicity of Chlorpyrifos and Diuron to Chickens and Rabbits|
|Title in Arabic||السمية طويلة الامد لمبيد الكلوروبيروفوس و مبيد الديرون على الدجاج و الارانب|
Background and Problem: Application of pesticide for agriculture and public health purposes, leaves low concentration of residues that may be harmful for the non target organism. Objectives and aims: The study characterize biochemical changes associated with long term toxicity of Chlorpyrifos and Diuron in chickens and rabbits. Methodology: Chlorpyrifos and Diuron were dissolved in corn oil and given to chicken and rabbits at rate of 0.1mg/ kg/ day, to 2 weeks period. The behavior daily activity and weight were monitored daily at the 8 weeks. The animals were authenticated, blood samples were collected in heborinzed tubes and kept under cold condition until analysis .Liver, kidney, heart and brain samples were collected for enzymes analysis. Evaluation of toxicity was determined by analyzing the activities of the following enzymes in the collected blood serum, liver, brain, kidney and heart tissue: 1) Acetylcholine esterase (AChE), 2) Alkaline phosphates (ALP), 3) Aspartate aminotransferase, AST, 4) Alanine aminotransferase (ALT), 5) Total protein, kidney factions, crecetine, uric acid, and urea. Results: Results showed reduced weights of rabbits and chicken due to repeated low does application. The effect of mixture in reducing rabbits weight was more pronounced than in Diuron or Chlorpyrifos. However the effect in chicken was more pronounced in Diuron treatments than Chlorpyrifos or mixture. Diuron treatments reduced the weight of liver in rabbits and increased it in chicken. Similar observation was in the heart weight in rabbit and chicken. All treatments elevated the levels of ALT in rabbit above the control sample whereas in chicken the ALT remained below the control sample. The treatment of mixture inhibited AChE in brain and serum in rabbets; whereas in chicken Diuron was the most toxic one. Mixture treatment elevated the level of uric acid and total protein above the control sample in rabbits; whereas Diuron treatments in chicken was more potent than others; and elevated urea, uric acid and total protein above the control. Conclusions: It can be concluded that rabbit and chicken have different responses to low repeated does application of Chlorpyrifos, Diuron, and mixture. The enzyme reacted differently in all case.
|Publisher||الجامعة الإسلامية - غزة|
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