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|Title||Toxic Effects of Cypermethrin on Liver and Kidney of Male Domestic Rabbits|
|Title in Arabic||أثر سمية مبيد cypermethrin على الكبد والكلية في ذكور الأرانب المحلية|
Objective: The present study is aimed to investigate the toxic effects of cypermethrin on liver and kidney of male domestic rabbits. Materials and Methods: The oral LD50 of cypermethrin in male domestic rabbit was calculated from logarithmic scale and found to be 665 mg/kg-1 body weight. A daily dose of 1/10 LD50 cypermethrin (66.5 mg/kg-1 body weight) was given orally to 36 animals under experiment for six weeks. Forty eight control animals were given distilled water. Blood samples were collected weekly and analyzed. Results: The overall mortality rate was 16.7% in cypermethrin-treated rabbits compared to 0.0% in controls. Clinical signs included diarrhea, disorientation, drowsiness and mild tremor. The final body weight was significantly decreased in cypermethrin-intoxicated rabbits. Serum glucose was significantly increased in response to cypermethrin administration recording a maximum percentage difference of 28.1% in the 6th week of the experiment. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (g-GT) were significantly higher in cypermethrin-treated rabbits compared to controls, registering maximum percentage differences of 30.1, 38.3, 23.1 and 27.5% during the 4th,1st, 2nd and 6th weeks of the experiment, respectively. In contrast, serum cholinesterase (ChE) was markedly decreased recording a maximum percentage difference of 46.5% during the 5th week of the experiment. Serum bilirubin was gradually increased to record a maximum percentage difference of 21.4% in the 5th week. Serum urea and creatinine concentrations were significantly elevated in response to cypermethrin intake displaying maximum percentage differences of 48.8% and 31.3% during the 6th and 5th weeks of the experiment, respectively. Serum total protein, albumin and globulin were significantly decreased upon cypermethrin intoxication exhibiting percentage differences of 31.3, 31.8 and 29.4% at the last week of the experiment. Serum calcium was significantly decreased in cypermethrin-treated rabbits with a maximum percentage difference of 28.6% at the 6th week whereas phosphorus significantly increased with a maximum percentage difference of 24.3% at the 6th week of the experiment. Conclusions: Oral daily administration of 1/10 LD50 cypermethrin caused significant decrease in body weight, serum cholinesterase, total protein, albumin, globulin and calcium whereas serum glucose, ALT, AST, ALP, g-GT, bilirubin, urea, creatinine and phosphorous were significantly increased.
|Publisher||الجامعة الإسلامية - غزة|
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