Evaluation of Insulin-Like Growth Factor Binding Protein-1 among Infertile Women with Poly Cystic Ovary Syndrome in Gaza Strip

Abstract

Background: Poly cystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women. It is thought to be one of the leading causes of female infertility. An elevated circulating concentration of insulin inhibits the production of insulin-like growth factor binding protein-1 (IGFBP-1), thus increasing the level of free IGF-I in serum and stimulating ovarian androgen production. Objective: to evaluate of IGFBP-1 and its relation to other reproductive hormones among Poly Cystic Ovary infertile women inGaza strip. Methodology: The study was a case control and carried out in Specialized Medical Centers in Gaza strip. A total of 40 women with PCOS infertility were face to face interview was used for filling questionnaire which is designated for matching the study need and blood analysis for IGFBP-1, Follicular Stimulating Hormone (FSH), Luteinizing Hormone (LH), Testosterone, Dehydroepiandrosterone-Sulfate (DHEA-S), Thyroid Stimulating Hormone (TSH) and Insulin were performed . Moreover, forty fertile women were served as controls and they have been selected on the basis of being married, having children and matching the case in age and residence. Statistical Package for the Social Sciences (SPSS) system was used to analyze the obtained data. Results: The mean body mass index (BMI) in patients compare to controls were (25.8 and 23.7) kg/m2, respectively. The mean of the serum IGFBP-1 levels were decreased significantly in the patients group compared to controls,(4.57 vs 9.2 ng/ml), (P=0.000). Moreover the serum LH, Testosterone, DHEAS–S, and Insulin were increased in patients compared to controls (18.77±7.05 vs 7.75± 2.14 mIU/ml, P=0.00) and (0.54±0.28 vs 0.35±0.18 ng/ml, P=0.00) and (2.06±1.01 v 1.0±0.43μg/ml, P=0.00) and (20.61±5.48 vs 6.86±1.62 mIU/ml), P=0.00), respectively. But the serum FSH, TSH were no significantly different between patients and controls (6.11±1.77 vs 6.0±2.09 mIU/ml,P=0.82) and (2.61±1.07 vs 2.84±1.42 mIU/ml, P=0.41), respectively. IGFBP-1 was negatively correlated with LH, Testosterone, DHEA-S, Insulin and BMI (r=-0.632,P=0.00),(r=-0.389,P=0.00), (r=-0.546,P=0.01), (r=-0.590,P=0.00) and (r=-0.411,P=0.00), respectively among the study population. Its correlation with other parameters FSH and TSH were not observed (P>0.05). Conclusion: The significance decrease in the serum IGFBP-1 levels between PCOS infertile women and fertile women suggests that this hormone is involved in pathophysiology of PCOS infertility. IGFBP-1 was negatively correlated with LH, Testosterone, DHEA-S and Insulin. In contrast, no significant correlation was observed between the IGFBP-1 and FSH or TSH hormones which suggests that physiological concentration of serum IGFBP-1 does not directly influence FSH and TSH production.