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|Title||Synthesis of New Acyl Hydrazones and their Conversion into 1,3,4-Oxadiazole Derivatives|
|Title in Arabic||تحضير اسيل هيدرازونات جديدة وتحويلها الى مشتقات 1و3و4-وكساديازول|
A series of N-acylhydrazone derivatives 86-89 was synthesized via condensation of nicotinic acid hydrazide 75 with different carbonyl compounds 76, 77, 84 and 85. The synthesized N-acylhydrazones 86-89 were reacted with acetic anhydride 90 to produce the 2,3-dihydro-1,3,4-oxadiazole derivitives 91-94 in good yield (60-65%). The structures of the products were confirmed by IR, LRMS, HRMS, 1HNMR and 13CNMR. The structure of compound 88 was determined by X-ray analysis.
|Publisher||الجامعة الإسلامية - غزة|
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