Browsing by Author "siwini"
Now showing items 1-17 of 17
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A novel binuclear palladacycle complex inhibits melanoma growth in vitro and in vivo through apoptosis and autophagy
(Elsevier BV, 2013-12)Malignant melanoma is an aggressive skin cancer and it is reported to be the most treatment-resistant human cancer. Here we describe the anti-tumour activity of a novel binuclear palladacycle complex (AJ-5) in vertical ... -
Anti carcinogenic Effect of Roman nettle Against chemical Induced Colon cancer in Sprague–Dawley Rats
(الجامعة الإسلامية - غزة, 2016)Colon cancer is an aggressive cancer and it is reported to be one of the most treatment-resistant human cancer. This article describes the anti-carcinogenic activity of Roman nettle (Urtica pilulifera) in comparison to ... -
Assessment of awareness and hygiene practices regarding COVID-19 among adults in Gaza, Palestine
(Elsevier BV, 2021-05)Coronavirus disease 2019 (COVID-19) has spread worldwide and become an emerging life-threatening pandemic disease since 2019. This study aimed to evaluate the basic knowledge, awareness, personal hygiene and healthy practices ... -
Combined Caffeine and Cisplatin Treatment Induces Synergistic Cytotoxicity in Hela Cell Line
(الجامعة الإسلامية - غزة, 2017)Cisplatin is a common alkylating anticancer agent that has been used to treat several cancers. However, the efficiency of cisplatin treatment is limited due to the severe side effects and the resistance to the drug, which ... -
Combined pitavastatin and dacarbazine treatment activates apoptosis and autophagy resulting in synergistic cytotoxicity in melanoma cells
(Spandidos Publications, 2017-10-16)Melanoma is an aggressive skin cancer and its incidence is increasing faster than any other type of cancer. Whilst dacarbazine (DTIC) is the standard chemotherapy for metastatic melanoma, it has limited success. Statins, ... -
Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents
(MDPI AG, 2021-07-02)Three novel pyrazolo-[4,3-e][1,2,4]triazolopyrimidine derivatives (1, 2, and 3) were designed, synthesized, and evaluated for their in vitro biological activity. All three compounds exhibited different levels of cytotoxicity ... -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
(Informa UK Limited, 2021-01-02)In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and ... -
Imidazo[1,2-a]pyridine Based Compounds: The Hopeful Anti-Cancer Therapy Review Article
(Wolters Kluwer Medknow Publications, 2021-04-11)Chemotherapy is a type of cancer treatment that uses a systemic drug to kill cancer cells wherever it finds in the body. It implements their actions through intervention with molecular mechanisms such as some core regulatory ... -
Newly Synthesized Palladium (II) Complex ASH10 Induces Apoptosis and Autophagy in Breast Cancer Cells
(2020)Background and Objective: Palladacycles have been reported to exert significant anticancer activities against different cancer cells. The current study conducted to evaluate the anti-tumor activity of a new palladacycle ... -
Novel imidazo[1,2‑a]pyridine inhibits AKT/mTOR pathway and induces cell cycle arrest and apoptosis in melanoma and cervical cancer cells
(Spandidos Publications, 2019-05-13)The present study aimed to investigate the anti‑cancer activity of imidazo[1,2‑a]pyridine 5‑7 in the A375 and WM115 melanoma and HeLa cervical cancer cell lines. The viability of cancer cells was analyzed by the MTT assay. ... -
Overexpression of TBX3 transcription factor as a potential diagnostic marker for breast cancer
(Spandidos Publications, 2018-11-09)The T-box 3 (TBX3) transcription factor has been shown to serve multiple roles in normal development. Recent findings have revealed that TBX3 is overexpressed in different types of carcinomas, including breast, cervical, ... -
Pitavastatin and Cancer: Current and Future Prospects
(Bentham Science Publishers Ltd., 2021-07-07)Pitavastatin is a synthetic 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor, which was approved for the primary treatment of hypercholesterolemia and combined dyslipidemia since 2009. Today, in vitro and in vivo ... -
Pitavastatin Enhances Doxorubicin-induced Apoptosis in MCF7 Breast Cancer Cells
(2020)Breast cancer is the most common malignancy in women worldwide. While doxorubicin is part of the standard therapy for metastatic breast cancer, it has limited success. Pitavastatin has been shown to enhance the anti-cancer ... -
Preparation, characterization and evaluation of novel 1,3,5-triaza-7-phosphaadamantane (PTA)-based palladacycles as anti-cancer agents
(Elsevier BV, 2017-11)A series of novel mononuclear 1,3,5-triaza-7-phosphaadamantane (PTA)-based palladacycles were prepared by cleaving μ-Cl binuclear orthopalladated dimers of substituted benzylidene-2,6-diisopropylphenylamines. All complexes ... -
TBX3 Role in Colorectal Cancer Treatment
(الجامعة الإسلامية - غزة, 2017)The T-box family of developmentally important transcription factors has been shown to play a role in the genesis of cancer and shows much promise for a targeted therapeutic approach. For example, the T-box factor TBX3 is ... -
The expression level of T‐box transcription factor TBX2 in breast cancer and its clinical significance
(VERDUCI PUBLISHER, VIA GREGORIO VII, ROME, ITALY, 186-00165, 2021-07-12)Objective: Recent studies showed that overexpression of T‐box transcription factor TBX2 in ovarian and prostate cancer tissues is associated with conferred resistance to chemotherapeutic drugs. However, whether TBX2 is ... -
The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells
(Elsevier BV, 2015-02)Breast cancer is the most common malignancy amongst women worldwide but despite enormous efforts to address this problem, there is still limited success with most of the current therapeutic strategies. The current study ...