Browsing by Author "siwini"
Now showing items 1-9 of 9
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A novel binuclear palladacycle complex inhibits melanoma growth in vitro and in vivo through apoptosis and autophagy
(Elsevier BV, 2013-12)Malignant melanoma is an aggressive skin cancer and it is reported to be the most treatment-resistant human cancer. Here we describe the anti-tumour activity of a novel binuclear palladacycle complex (AJ-5) in vertical ... -
Anti carcinogenic Effect of Roman nettle Against chemical Induced Colon cancer in Sprague–Dawley Rats
(الجامعة الإسلامية - غزة, 2016)Colon cancer is an aggressive cancer and it is reported to be one of the most treatment-resistant human cancer. This article describes the anti-carcinogenic activity of Roman nettle (Urtica pilulifera) in comparison to ... -
Combined Caffeine and Cisplatin Treatment Induces Synergistic Cytotoxicity in Hela Cell Line
(الجامعة الإسلامية - غزة, 2017)Cisplatin is a common alkylating anticancer agent that has been used to treat several cancers. However, the efficiency of cisplatin treatment is limited due to the severe side effects and the resistance to the drug, which ... -
Combined pitavastatin and dacarbazine treatment activates apoptosis and autophagy resulting in synergistic cytotoxicity in melanoma cells
(Spandidos Publications, 2017-10-16)Melanoma is an aggressive skin cancer and its incidence is increasing faster than any other type of cancer. Whilst dacarbazine (DTIC) is the standard chemotherapy for metastatic melanoma, it has limited success. Statins, ... -
Novel imidazo[1,2‑a]pyridine inhibits AKT/mTOR pathway and induces cell cycle arrest and apoptosis in melanoma and cervical cancer cells
(Spandidos Publications, 2019-05-13)The present study aimed to investigate the anti‑cancer activity of imidazo[1,2‑a]pyridine 5‑7 in the A375 and WM115 melanoma and HeLa cervical cancer cell lines. The viability of cancer cells was analyzed by the MTT assay. ... -
Overexpression of TBX3 transcription factor as a potential diagnostic marker for breast cancer
(Spandidos Publications, 2018-11-09)The T-box 3 (TBX3) transcription factor has been shown to serve multiple roles in normal development. Recent findings have revealed that TBX3 is overexpressed in different types of carcinomas, including breast, cervical, ... -
Preparation, characterization and evaluation of novel 1,3,5-triaza-7-phosphaadamantane (PTA)-based palladacycles as anti-cancer agents
(Elsevier BV, 2017-11)A series of novel mononuclear 1,3,5-triaza-7-phosphaadamantane (PTA)-based palladacycles were prepared by cleaving μ-Cl binuclear orthopalladated dimers of substituted benzylidene-2,6-diisopropylphenylamines. All complexes ... -
TBX3 Role in Colorectal Cancer Treatment
(الجامعة الإسلامية - غزة, 2017)The T-box family of developmentally important transcription factors has been shown to play a role in the genesis of cancer and shows much promise for a targeted therapeutic approach. For example, the T-box factor TBX3 is ... -
The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells
(Elsevier BV, 2015-02)Breast cancer is the most common malignancy amongst women worldwide but despite enormous efforts to address this problem, there is still limited success with most of the current therapeutic strategies. The current study ...