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    • Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice

      Schäfer, Matthias; Willrodt, Ann‐helen; Kurinna, Svitlana; Link, Andrea S; Farwanah, Hany; Geusau, Alexandra; Gruber, Florian; Sorg, Olivier; Huebner, Aaron J; Roop, Dennis; Sandhoff, Konrad; Saurat, Jean‐hilaire; Tschachler, Erwin; Schneider, Marlon R; Langbein, Lutz; Bloch, Wilhelm; Beer, Hans‐dietmar; Werner, Sabine (EMBO Press, 2014)
      The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacological Nrf2 activation is a promising strategy for skin protection and cancer prevention. We show here that prolonged Nrf2 ...
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      Nrf2 links epidermal barrier function with antioxidant defense

      Schäfer, Matthias; Farwanah, Hany; Willrodt, Ann‐helen; Huebner, Aaron J; Sandhoff, Konrad; Roop, Dennis; Hohl, Daniel; Bloch, Wilhelm; Werner, Sabine (EMBO Press, 2012)
      The skin provides an efficient permeability barrier and protects from microbial invasion and oxidative stress. Here, we show that these essential functions are linked through the Nrf2 transcription factor. To test the ...