• العربية
    • English
  • English 
    • العربية
    • English
  • Login
Home
Publisher PoliciesTerms of InterestHelp Videos
Submit Thesis
IntroductionIUGSpace Policies
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
  •   Home
  • Faculty of Medicine
  • Staff Publications- Faculty of Medicine
  • View Item
  •   Home
  • Faculty of Medicine
  • Staff Publications- Faculty of Medicine
  • View Item

Please use this identifier to cite or link to this item:

http://hdl.handle.net/20.500.12358/24425
TitleAdult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas
Untitled
Abstract

(Dihydro) ceramide synthase 2 (cers2, formerly called lass2) is the most abundantly expressed member of the ceramide synthase gene family, which includes six isoforms in mice. CERS2 activity has been reported to be specific toward very long fatty acid residues (C22–C24). In order to study the biological role of CERS2, we have inactivated its coding region in transgenic mice using gene-trapped embryonic stem cells that express lacZ reporter DNA under control of the cers2 promoter. The resulting mice lack ceramide synthase activity toward C24: 1 in the brain as well as the liver and show only very low activity toward C18: 0–C22: 0 in liver and reduced activity toward C22: 0 residues in the brain. In addition, these mice exhibit strongly reduced levels of ceramide species with very long fatty acid residues (≥ C22) in the liver, kidney, and brain. From early adulthood on, myelin stainability is progressively lost …

Authors
Imgrund, Silke
Hartmann, Dieter
Farwanah, Hany
Eckhardt, Matthias
Sandhoff, Roger
Degen, Joachim
Gieselmann, Volkmar
Sandhoff, Konrad
Willecke, Klaus
TypeJournal Article
Date2009
Published inJournal of Biological Chemistry
SeriesVolume: 284, Number: 48
PublisherAmerican Society for Biochemistry and Molecular Biology
Citation
Item linkItem Link
License
Collections
  • Staff Publications- Faculty of Medicine [149]
Files in this item
Farwanah, Hany_0.pdf5.036Mb
Thumbnail

The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

Contact Us | Send Feedback
 

 

Browse

All of IUGSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsSupervisorsThis CollectionBy Issue DateAuthorsTitlesSubjectsSupervisors

My Account

LoginRegister

Statistics

View Usage Statistics

The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

Contact Us | Send Feedback