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http://hdl.handle.net/20.500.12358/24424
TitleThyroxin, glucose, body growth rate and non-protein nitrogen constituents in albino rats treated with excess potassium iodate
Untitled
Abstract

The study was aimed to determine median lethal dose (LD50) of potassium iodate and to assess its toxicity in albino rats. The oral LD50 was found to be 752 mg kgí1 body weight. A dose of 1/5 LD50 potassium iodate was then given to animals (n= 36). Control animals (n= 36) received distilled water. Means were compared by independent-samples t-test. Growth rates of experimental animals were decreased, particularly at the first two weeks (27.5 and 24.2%, p= 0.009 and 0.000, respectively). Significant increase in serum thyroxin was observed at the second and third weeks (p= 0.007 and 0.046, respectively). Mean glucose levels were significantly decreased with maximum difference of 26.3% at the fifth week (106.1±4.9 v 78.2±4.2, p= 0.002). Urea was decreased (max difference= 23.6%, mean= 35.6±1.8 v 27.2±1.7, p= 0.007) whereas uric acid and creatinine were increased (max difference= 25.4%, mean= 1.77±0.08 v 2.22±0.12, p= 0.011 and 19.6%, 0.56±0.03 v 0.67±0.03, p= 0.022, respectively).

Authors
Yassin, Maged M.
Abdel Aziz, Ismail I.
EL Mabhouh, Fayez A
TypeJournal Article
Date2008
Subjects
non-protein nitrogen constituents
thyroxin
albino rats
body growth rate
glucose
potassium iodate toxicity
Published inInternational Journal of Food Safety, Nutrition and Public Health
SeriesVolume: 1, Number: 2
PublisherInderscience Publishers
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  • Staff Publications- Faculty of Medicine [149]
  • Staff Publications- Faculty of Science [1030]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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